Woman hiking at sunrise - MOTS-c peptide therapy in Boise & Meridian, ID at Alturas Medical Weight Loss
Dr. Ashley Southern, NMD
Physician-Supervised CareGuided by Dr. Ashley Southern, NMD
MOTS-c Consultations Available Now

MOTS-c Peptide Therapy in Boise & Meridian, ID

Looking to improve energy, athletic performance and improve your weight loss journey? See if MOTS-c, a peptide your own mitochondria makes is a good fit for you!

Common goals Treasure Valley patients bring to us:

  • Metabolic health and blood sugar.
  • Body composition, alongside a weight-loss plan.
  • Energy and exercise capacity.
  • Healthy aging.

Who we serve: Adults focused on metabolism and healthy aging from Boise, Meridian, Eagle, Nampa and Star. Our Meridian clinic is 15–20 minutes from downtown Boise. See all peptide therapy in Boise.

Free 15-minute consultation · No obligation

4.9 from 120+ Google reviews

Physician-Prescribed

Medical evaluation before treatment

Made in the USA

Every peptide we prescribe is made in the United States

Meridian Clinic

Serving patients throughout the Treasure Valley

Before You Book: What to Know About MOTS-c

  • MOTS-c is a small peptide your own mitochondria make. Researchers are studying it for metabolism and blood sugar.
  • Most of what we know comes from mice. The first real human trial started this year, so there are no results yet.
  • It isn’t FDA-approved. A new federal policy may let pharmacies make it with a prescription, but that’s not the same as approval.
  • It’s not for you if you’re a tested athlete, pregnant or breastfeeding.
  • We’re in Meridian, about 15–20 minutes from downtown Boise. Your first visit is a free 15-minute consult with Dr. Ashley Southern.

What Is MOTS-c?

MOTS-c is a small peptide your body makes. It is a chain of 16 amino acids.

  • Made by your mitochondria: it is coded in mitochondrial DNA, not the cell nucleus.
  • Studied for metabolism: in animal research, it acts mainly on muscle and how the body handles glucose.
  • Rises with exercise: in a small study, exercise raised MOTS-c in muscle about 12-fold.
  • Physician-prescribed: made in the USA, after a medical evaluation.

Working on weight loss? See our medical weight loss program.

Microscope image of human cells - what is MOTS-c, a mitochondrial peptide

Why Patients Choose MOTS-c

Patients ask about MOTS-c to support:

  • Metabolic health: blood sugar and insulin sensitivity.
  • Body composition alongside a weight-loss plan.
  • Energy and exercise capacity.
  • Healthy aging for active adults.

Results vary, and human research is still early. Dr. Southern will tell you plainly what to expect.

Active older woman running in a park - MOTS-c peptide therapy in Boise & Meridian, ID

Physician-guided careEvery MOTS-c plan starts with a one-on-one evaluation in Meridian

Who Is a Good Candidate for MOTS-c?

Great fit for

  • Adults working on weight loss or blood sugar who want to discuss more options.
  • Active adults focused on energy, training and healthy aging.
  • Anyone who wants physician oversight instead of “research peptides” sold online.

Not a fit

  • Tested athletes
  • Pregnant or breastfeeding
  • Active or past cancer

How It Works

1
Free consultationYour goals, medications and health history.
2
Your planLabs when medically appropriate, then a custom MOTS-c protocol.
3
Follow-upWe track your progress and adjust.

Why Choose Alturas for MOTS-c?

  • Physician-guided care: Dr. Ashley Southern, NMD, reviews your history, medications and goals.
  • Weight-loss expertise: we weigh MOTS-c against proven options like GLP-1 medications.
  • Honest answers: We separate what research shows from marketing claims.
  • Lab work when it matters: We order labs whenever they are medically appropriate.
  • US-made peptides: Every peptide we prescribe is made in the United States.
  • Follow-up care: We monitor how you respond when ongoing care is appropriate.

Our clinic is at 1532 W Cayuse Creek Dr in Meridian, about 15–20 minutes from Boise.

Dr. Ashley Southern, NMD, at Alturas Medical Weight Loss in Meridian

What the Evidence Shows

Researcher at a microscope - what the evidence shows on MOTS-c

What people hope for, and what research actually shows.

Blood sugar and insulin sensitivityAnimal studiesIn mice, MOTS-c prevented insulin resistance from age and a high-fat diet. A human trial in adults with prediabetes is now underway.
Weight loss in peopleNot establishedMice on a high-fat diet gained less weight. In the only human study (a lab-made version, 4 weeks), weight change was not significant.
Exercise capacity and agingAnimal studiesOlder mice given MOTS-c for 2 weeks ran about twice as long. In people, exercise raises your own MOTS-c, but taking it has not been tested for this.
MOTS-c given by injection in peopleBeing studiedA 120-person phase 2a trial started in 2026. No results have been published yet.

Sources

Where this information comes from

Last reviewed: November 2026

Animal studyCell Metabolism · 2015The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceThe discovery paper. In mice, MOTS-c prevented diet-induced obesity and insulin resistance. Main target: muscle.Lee et al.Journal →Human + animalNature Communications · 2021MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical declineExercise raised MOTS-c about 12-fold in the muscle of 10 young men. Treated older mice ran about twice as long.Reynolds et al.Journal →Clinical trialCompany release · Aug 2021Phase 1a/1b study of CB4211, a lab-made MOTS-c analog20 adults with obesity and fatty liver, 4 weeks. Liver enzymes and glucose fell vs. placebo; weight change was not significant.CohBar via BioSpaceArticle →Ongoing trialClinicalTrials.gov · 2026MOTS-c for improving insulin sensitivity in adults with prediabetes and overweight/obesityPhase 2a, 120 adults, daily injection for 12 weeks vs. placebo. Recruiting; no results yet.NCT07505745Registry →RegulatoryAJMC · Oct 20265 things to know about HHS’s interim peptide compounding policyHHS proposed letting licensed pharmacies compound MOTS-c and five other peptides while FDA rulemaking is pending. It is not FDA approval.AJMCArticle →Anti-dopingUSADA · 2026What is MOTS-c?Banned in sport at all times (WADA S4.4, AMPK activator). Notes that MOTS-c itself has no completed human trials.USADAWebsite →

Safety and FDA Status

Not FDA-approved

MOTS-c is not an approved drug in the U.S.

Compounding rules are changing

An FDA panel voted 7–5 for compounding in July 2026. HHS proposed an interim policy in October. Neither is approval.

Banned in sport

WADA has banned MOTS-c at all times since 2025. Tell us if you are a tested athlete.

  • Human safety data is limited: MOTS-c itself has no completed human trials.
  • Lab-made version: well tolerated over 4 weeks; mild injection-site reactions were most common.
  • Tell us everything: medications, supplements and conditions, especially diabetes or weight-loss medications.
  • Skip “research peptides” sold online.
Clinician drawing blood for lab work before MOTS-c peptide therapy in Meridian, ID

MOTS-c Consultations Near Boise and Meridian

Patients come to our Meridian clinic from across the Treasure Valley, including Boise, Eagle, Nampa, Star, Middleton, Kuna, Caldwell and Garden City.

We also offer medical weight loss and hormone therapy.

Location: 1532 W Cayuse Creek Dr, Meridian, ID 83646
Phone: (208) 690-2040

Book your MOTS-c consultation today.

Meet Our Medical Team

Dr. Ashley Southern, supervising physician at Alturas Medical Weight Loss in Meridian, ID

Dr. Ashley Southern, NMD

Dr. Ashley Southern is the physician and co-founder of Alturas Medical Weight Loss. She evaluates peptide therapy within the context of each patient’s medical history, medications and laboratory results.

The goal is to determine whether a specific therapy is medically appropriate.

Frequently Asked Questions About MOTS-c

Where can I get MOTS-c therapy near Boise?

Alturas Medical Weight Loss in Meridian, about 15 to 20 minutes from Boise, offers physician-guided MOTS-c consultations. We are at 1532 W Cayuse Creek Dr. Call (208) 690-2040 to book a free 15-minute consult.

What is MOTS-c?

MOTS-c is a 16-amino-acid peptide your mitochondria make. It is coded in mitochondrial DNA. Animal research links it to how muscle uses glucose. Exercise raises your own levels.

Does MOTS-c help with weight loss?

Not proven in people. In mice, it prevented diet-induced weight gain. The only human study, of a lab-made version, found no significant weight change over 4 weeks. For proven options, see our medical weight loss program.

How is MOTS-c given?

As a small injection under the skin. The human trial now underway uses a once-daily injection for 12 weeks. If MOTS-c is right for you, Dr. Southern sets your dose and schedule.

How soon will I notice results?

We can’t promise a timeline. MOTS-c has no published human results yet, and some people notice no change. We set clear goals at your first visit and check your progress at each follow-up.

Is MOTS-c FDA-approved?

No. In July 2026, an FDA advisory committee voted 7–5 to allow pharmacy compounding. In October 2026, HHS proposed an interim compounding policy. Neither approves MOTS-c, and compounded medications are not FDA-approved.

Is MOTS-c safe?

We don’t know yet. MOTS-c itself has no completed human trials. A lab-made version was well tolerated over 4 weeks, with mostly mild injection-site reactions. Long-term safety is unknown.

Can I take MOTS-c with semaglutide or tirzepatide?

This combination has not been studied. Dr. Southern reviews every medication first, including semaglutide and tirzepatide, before recommending anything.

Can athletes use MOTS-c?

No. MOTS-c has been banned in sport at all times under World Anti-Doping Agency rules since 2025. Tested athletes should not use it.

Free 15-minute consult

See if MOTS-c Is Right for You

Meet our Meridian medical team. Here is what happens next:

1Book your free consult
2Share your goals and history
3Medication and lab review
4Risks and options explained
5Your personal plan

Prefer to talk? Call or text (208) 690-2040

Meet Dr. Ashley SouthernPhysician-led care, NMDBlogGuides on weight loss, hormones and peptidesBMI CalculatorCheck your BMI in under a minute
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